Re: Vitamin D Defficiency and Mobility Issues in Old People
Originally Posted by Artangel
Realist, l have never been offered, or instructed to take Vitamin K. Should l have been?
Some research to consider:
"Taking a Vitamin D3 supplement without K2 can have disastrous effect, as Vitamin D creates need for Vitamin K2 in the body.
As a guide, you should take 45mcg of Vitamin K2 per 1000 IU of Vitamin D3."
"Take your Vitamin K2 supplement with your dinner that includes dietary fat or at bedtime, 8 to 12 hours after you take your Vitamin D3.
Most people take their D3 with breakfast and K2 at dinner time and this seems sensible, as some research shows that D3 is more effective if not taken at the same time as K2."
If you want a more mainstream link then here's one from NCBI:
"Given the fact that 25(OH)D is converted to 1,25(OH)D, vitamin D supplementation stimulates the production of 1,25(OH)D . This means that long-term vitamin D supplementation could promote the production of large amounts of vitamin K-dependent proteins, which remain inactive because there is not enough vitamin K to carboxylate (Figure 1()). We propose a new hypothesis that if vitamin D concentrations are constantly high, there might not be enough vitamin K for activation of vitamin K-dependent proteins. Consequently, excess vitamin D diminishes the ability of vitamin K-dependent proteins to function properly, to stimulate bone mineralization, and to inhibit soft tissue calcification"
"increasing vitamin D intake through dietary or supplemental source increases intestinal calcium absorption, particularly when combined with calcium supplementation, and promotes hypercalcemia "
"Increased calcium intake by itself may not be problematic as long as there is a steady state between optimal vitamin D and vitamin K concentrations. The disbalance between vitamin D and vitamin K promotes an environment in which excess calcium will be deposited into our vascular tissue instead of bone. "